Korean J Pathol.  2011 Feb;45(1):15-20.

Prognostic Implications of the Expression of CXCL16 in Breast Carcinoma

• Choi DY
• Hong R
• Lim SC
• Kee KH
• Suh CH
• Lee M

Abstract

BACKGROUND
Of the many prognostic factors for breast cancer, the relationship between an infiltration of inflammatory cells and the prognosis is debatable. Of the chemokines affecting cancer's inflammatory reactions, chemokine (C-X-C motif) ligand 16 (CXCL16) has attracted attention for its prognostic value in many cancers, including colorectal cancer and renal cell carcinoma. But the situation for breast carcinoma is unknown. The aim of this study was to examine the relationship between the prognostic factors and the CXCL16 expression in patients with breast carcinoma.
METHODS
The patients (n=106) diagnosed with invasive ductal cancer of the breast were enrolled. We reviewed the clinicopathological factors of these patients, hematoxylin and eosin stains were prepared and estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2/neu) and CXCL16 immunostaining was performed.
RESULTS
The ER expression was significantly correlated with age and inflammation. A CXCL16 expression was noted in 81.1% of the cases. No association was evident between a CXCL16 expression and any other parameter, including the survival rate. Multivariate analysis did not implicate ER, HER2/neu or CXCL16 as an independent prognostic factor, but the tumor size was independent predictive factor for the patient outcome.
CONCLUSIONS
An inflammatory reaction mediated by CXCL16 is not associated with the prognosis of breast cancer or any clinicopathological factors.

Keyword

Breast neoplasms; CXCL16 protein, human; Prognosis; Survival

MeSH Terms

Breast
Breast Neoplasms
Carcinoma, Renal Cell
Chemokines
Chemokines, CXC
Colorectal Neoplasms
Coloring Agents
Eosine Yellowish-(YS)
Estrogens
Hematoxylin
Humans
Inflammation
Multivariate Analysis
Prognosis
Receptor, Epidermal Growth Factor
Receptor, erbB-2
Receptors, Scavenger
Survival Rate
Chemokines
Chemokines, CXC
Coloring Agents
Eosine Yellowish-(YS)
Estrogens
Hematoxylin
Receptor, Epidermal Growth Factor
Receptor, erbB-2
Receptors, Scavenger