Korean J Pathol.
2013 Apr;47(2):124-129.
No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
- Affiliations
-
- 1Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea. soonheej@yonsei.ac.kr
- 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 3Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
- 5Department of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea.
- 6Department of Pathology, Inha University School of Medicine, Incheon, Korea.
- 7Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
- 8Department of Pathology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.
- 9Department of Pathology, The Catholic University College of Medicine, Seoul, Korea.
- 10Department of Pathology, Busan National University School of Medicine, Busan, Korea.
- 11Department of Pathology, Inje University College of Medicine, Busan, Korea.
- 12Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
- 13Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea.
Abstract
- BACKGROUND
Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA.
METHODS
We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA.
RESULTS
Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls.
CONCLUSIONS
SV40 is not associated with the development of MM in Korea.
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