Korean J Pathol.
2013 Jun;47(3):227-237.
Proposal for a Standardized Pathology Report of Gastroenteropancreatic Neuroendocrine Tumors: Prognostic Significance of Pathological Parameters
- Affiliations
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- 1Department of Pathology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicirne, Wonju, Korea.
- 2Department of Pathology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhpath.sohn@samsung.com
- 3Department of Pathology, Soon Chun Hyang University Hospital, Soon Chun Hyang University College of Medicine, Seoul, Korea.
- 4Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.
- 6Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 7Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 8Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- 9Department of Pathology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
- 10Department of Pathology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
- 11Department of Pathology, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.
- 12Department of Pathology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
- 13Department of Pathology, Kyunghee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
- 14Division of Statistics in Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Abstract
- BACKGROUND
There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients.
METHODS
We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report.
RESULTS
Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms.
CONCLUSIONS
A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEP-NET.
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