Korean J Pathol.  2013 Aug;47(4):383-387.

Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary

Affiliations
  • 1Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. soojinmd@hanmail.net

Abstract

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

Keyword

Sebaceous carcinoma; Sebaceous adenoma; Mature cystic teratoma; Ovary

MeSH Terms

Basophils
Carcinoembryonic Antigen
Female
Hair
Humans
Hysterectomy
Keratin-19
Keratin-7
Keratins
Molecular Weight
Mucin-1
Ovary
Pelvic Pain
Teratoma
Carcinoembryonic Antigen
Keratin-19
Keratin-7
Keratins
Mucin-1
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