Korean J Otorhinolaryngol-Head Neck Surg.  2011 Jun;54(6):419-422. 10.3342/kjorl-hns.2011.54.6.419.

A Case of Postradiation Chondrosarcoma of the Sphenoid and Clivus

• Lim GH
• Kim JK
• Shin SH

• KMID: 2277248
• DOI: http://doi.org/10.3342/kjorl-hns.2011.54.6.419

Abstract

Radiation-induced chondrosarcoma is very rarely encountered in the head and neck malignancy. Rate of chondrosarcoma is 9% of all radiation-induced bone sarcomas. Postradiation chondrosarcoma, like their spontaneous counterparts, are relatively radioresistant tumors, and prompt radical surgery has been the mainstay of therapy. However, not all postradiation chondrosarcoma are amenable to radical surgery. The location of the tumor is one of the most important factors in choosing a therapeutic modality and significantly influences the survival rate. The authors experienced a case of chondrosarcoma of the sphenoid sinus and clivus accompanying sixth and ninth cranial nerve palsies after radiation therapy of nasopharyngeal carcinoma.

Keyword

Nasopharyngeal carcinoma; Radiation therapy; Chondrosarcoma

MeSH Terms

Chondrosarcoma
Cranial Fossa, Posterior
Glossopharyngeal Nerve
Head
Nasopharyngeal Neoplasms
Neck
Paralysis
Sarcoma
Sphenoid Sinus
Survival Rate
Nasopharyngeal Neoplasms