Korean J Otorhinolaryngol-Head Neck Surg.  2007 Dec;50(12):1103-1108.

Plasma Levels of MCP-1, RANTES and IL-18 in Perennial Allergic Rhinitis Patients

• Park DS
• Lee JH

Abstract

BACKGROUND AND OBJECTIVES: Plasma levels of MCP-1, RANTES and IL-18 are related to allergic diseases such as atopic dermatitis or asthma. But it is not well investigated in allergic rhinitis. We evaluated the association of plasma concentrations of these cytokines and allergic rhinitis.
SUBJECTS AND METHOD
The concentrations of plasma MCP-1, RANTES and IL-18 were analyzed by ELISA. The levels of cytokines were compared between perennial allergic rhinitis patients (n=48) and controls (n=33), and this depended on symptom severity.
RESULTS
Plasma levels of MCP-1 and IL-18 were significantly increased more in allergic rhinitis patients (MCP-1, 108 pg/mL, p<0.01; IL-18, 299 pg/mL, p<0.01) than in controls (MCP-1, 86 pg/mL; IL-18, 168 pg/mL). Especially, the levels of moderate-severe allergic rhinitis group (MCP-1, 116 pg/mL; IL-18, 329 pg/mL) showed higher tendency than mild one (MCP-1, 101 pg/mL; IL-18, 273 pg/mL). However, the levels of RANTES did not exhibit any differences between allergic rhinitis and control.
CONCLUSION
Our results suggest that plasma MCP-1 and IL-18 might be associated with nasal inflammation of perennial allergic rhinitis, especially in severely symptomatic patients.

Keyword

Rhinitis; Plasma; Monocyte Chemoattractant Proteins-1; RANTES; Interleukin-18

MeSH Terms

Asthma
Chemokine CCL5*
Cytokines
Dermatitis, Atopic
Enzyme-Linked Immunosorbent Assay
Humans
Inflammation
Interleukin-18*
Plasma*
Rhinitis*
Chemokine CCL5
Cytokines
Interleukin-18