Korean J Otolaryngol-Head Neck Surg.  2005 Jan;48(1):61-64.

A Study of Susceptibility between Allergic Rhinitis and IL-13 Exon 4 G2044A Gene Polymorphism Study in Korean

Affiliations
  • 1Department of Otolaryngology, College of Medicine, Wonkwang University, School of Medicine, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
  • 2Department of Anatomy, College of Medicine, Wonkwang University, School of Medicine, Iksan, Korea.
  • 3Genomic Research Center for Immune Disorder, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine, Iksan, Korea.

Abstract

BACKGROUND AND OBJECTIVES
High total serum IgE level is one of the characteristics seen in allergic rhinitis. IL-13 provides impetus to immunoglobulin class switching to IgE. The IL-13 promoter single nucleotide polymorphism has been shown to be associated with allergic diseases and abnormal IL-13 production. We tested whether a polymorphism in the coding region of IL-13 gene is associated with allergic rhinitis, blood eosinophil counts and total serum IgE levels in Korean. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 307 individuals with allergic rhinitis and from 268 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for IL-13 exon 4 G2044A was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per microl. RESULTS: There were no differences in the frequencies of the genotypes of IL-13 in the controls and patients (p>0.05). The frequencies of the IL-13 exon 4 2044A allele were statistically different between controls and patients (p<0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of IL-13 exon 4 G2044A in allergic rhinitis (p>0.05). CONCLUSION: Our result suggests that the IL-13 exon 4 G2044A polymorphism might give susceptibility to the development of allergic rhinitis in Koreans.

Keyword

IL-13; Rhinitis allergic; Korean; Polymorphism

MeSH Terms

Alleles
Cell Count
Clinical Coding
Eosinophils
Exons*
Genotype
Humans
Immunoassay
Immunoglobulin Class Switching
Immunoglobulin E
Interleukin-13*
Polymorphism, Single Nucleotide
Rhinitis*
Immunoglobulin E
Interleukin-13
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