Korean J Otolaryngol-Head Neck Surg.  2004 Dec;47(12):1261-1266.

The Effect of Allergen Provocation on the Nasal Cycle

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kon-Kuk University, Seoul, Korea. jkkimmd@konkuk.ac.kr
  • 2Cham Otolaryngologic Clinic, Seoul, Korea.


Nasal airflow is asymmetrical and is subjected to spontaneous reciprocal changes which are referred to as the nasal cycle. Limited information is available about how they are affected by allergens. The purpose of this study was to evaluate effects of allergen provocation on the nasal cycle. SUBJECTS AND METHOD: This study was performed in 11 patients with allergic rhinitis and 6 healthy controls. Acoustic rhinometry was used to test subjects before and after the allergen provocation. The subjects underwent acoustic rhinometry in 15 minutes interval for evaluation of nasal cycle and 3 minutes interval for immediate response. RESULTS: With the allergic subjects, 10 of the 11 subjects (90.9%) showed nasal cycle and they still had nasal cycle after the allergen provocation. In the study on the changes of the immediate responses, recovery time was on the average of 33.0 minutes and reduction rate of non-patent side was higher than that of patient side. And the period of nasal cycle was on the average of 173 minutes before the allergen provocation and the average 159 minutes after the allergen provocation; there were no statistical differences. The amplitude of each nasal cycle increased after allergen provocation and the difference had statistical meaning. CONCLUSION: Overall duration and reciprocity of nasal cycle were not changed after the allergen provocation and the amplitude of nasal cycle was increased significantly after the allergen provocation.


Nasal mucosa , activity cycle; Rhinitis, allergic, perennial; Nasal provocation test; Acoustic rhinometry

MeSH Terms

Nasal Provocation Tests
Rhinitis, Allergic, Perennial
Rhinometry, Acoustic
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