Korean J Pathol.  1999 Nov;33(11):1102-1106.

Polyvesicular Vitelline Tumor of the Ovary: A case report

• Moon WS
• Lee DG

Abstract

Polyvesicular vitelline tumor of the ovary is an extremely rare variant of yolk sac tumor. We present a case of pure polyvesicular vitelline tumor in a 43-year-old woman. Light microscopy revealed a predominantly polyvesicular pattern embedded in mesoblastic stroma with the cysts showing two type of lining; tall columnar and cuboidal, or mesothelioid cells. The lining atypical cells showed occasional mitoses and intracytoplasmic PAS positive hyaline globules. In some areas, the cystic space contained a large amount of intraluminal hyaline material. Immunohistochemically, alpha- fetoprotein and alpha-1-antitrypsin were detected as a fine granular deposit in the cytoplasm of epithelial cells and hyaline globules. Electron microscopically, marked specialization of the vesicular lining cells suggested a differentiation toward gut structures and mature yolk sac.

Keyword

Polyvesicular vitelline tumor; Yolk sac

MeSH Terms

Adult
Cytoplasm
Endodermal Sinus Tumor
Epithelial Cells
Female
Fetal Proteins
Humans
Hyalin
Microscopy
Mitosis
Ovary*
Vitellins*
Yolk Sac
Fetal Proteins
Vitellins