Chonnam Med J.
1997 Dec;33(2):265-270.
Effects of Caspsaicin on Thermoregulation of Interscapular Brown Adipose Tissue in Rats
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University, Kwangju, Korea.
- 2Department of Biochemistry, Chonnam National University, Kwangju, Korea.
- 3National Institute of Health and Nutrition, Japan.
Abstract
- This Studied included observation of effects of capsaicin on thermogenesis of interscapular bwown adipose tissue of male Wistar rats. And the results were as follows. 1. Capsaicin(5mg/kg, S.C.) increased temperature of IBAT 0.24+/-0.05degreeC than colon termperature at 400min, and 0.10+/-0.08degreeC in muscle, however, there was no change in the liver by capsaicin administration. 2. Pretreatment with capsazepine(10mg/kg, SC) and denervation of intercostal nerves in IBAT blocked the inhibitory effect of capsaicin(1mg/kg,S.C.) on noradenaline-induced thermogenesis in IBAT. 3. Subcutaneous injection of capsicin(1mg/kg) attenulated the increase in temperature of IBAT induced by VMH stimulation (from 1.01+/-0.12degreeC to 0.28+/-0.07degreeC) which was persist for 3 hours after capsaicin injection. These results suggest that major site of thermogenesis by capsaicin administration is IBAT, and capsaicin may act through peripheral and central routes for control of thermogenesis.
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