Chonnam Med J.  2002 Dec;38(4):315-321.

Perfusion MR Imaging of Acute Cerebral Infarction in a Rabbit Model: Assessment of Cerebral Blood Flow

• Seo JJ
• Im NR
• Jeong GW
• Yoon W
• Kim YH
• Jeong YY
• Chung TW
• Kim JK
• Park JG
• Kang HK

Abstract

The present study was undertaken to evaluate the usefulness of cerebral perfusion MR imaging (PWI) in rabbit models with acute cerebral ischemic infarction. Experimental cerebral infarction were induced by direct injection of mixture of Histoacryl glue, lipiodol, and tungsten powder into the internal cerebral artery of 6 New-Zealand white rabbits, and they underwent MR imaging and PWI within 1 hour after the occlusion of internal cerebral artery. The PWI scan for each rabbit was obtained at the level of lateral ventricle and 1cm cranial to the basal ganglia. By postprocessing using special imaging software, perfusion images including CBV, CBF, MTT, and TTP maps were calculated and obtained. The detection of infarcted lesion were evaluated on each perfusion maps and T2-weighted MR imaging (T2 WI). MTT and TTP delay time were measured in the perfusion defect lesion and symmetric contralateral normal cerebral hemisphere. In all rabbits, all PWI maps showed the perfusion defect lesion. But T2WI did not revealed any abnormal high signal intensity. There were remarkable MTT and TTP delay in perfusion defect lesion. The mean TTP delay time was 4.1 seconds, and the mean MTT delay time was 2.9 seconds. In four of six rabbits, the area of infarcted lesion in MTT map measured larger than that of CBF map. PWI may be useful in diagnosing acute cerebral ischemic infarction and in evaluating the cerebral hemodynamics in the rabbits.

Keyword

Brain; MR; Perfusion; Experimental; Cerebral infarction

MeSH Terms

Adhesives
Basal Ganglia
Brain
Cerebral Arteries
Cerebral Infarction*
Cerebrum
Enbucrilate
Ethiodized Oil
Hemodynamics
Infarction
Lateral Ventricles
Magnetic Resonance Imaging*
Perfusion*
Rabbits
Tungsten
Adhesives
Enbucrilate
Ethiodized Oil
Tungsten