Korean J Otolaryngol-Head Neck Surg.  2000 Dec;43(12):1323-1327.

Reconstruction of Septal Perforation with Alloderm

• Lee HM
• Kim ST
• Cho JH
• Lee JH
• Choi CS
• Hwang SJ
• Lee SH

Abstract

BACKGROUND AND OBJECTIVES: The closure of nasal septal perforation is a significant surgical challenge with high failure rates. Acellular human dermal graft (Alloderm) placed between mucoperichondrial advancement flaps may be an alternative. The purpose of this study was to investigate the usefulness of Alloderm for the repair of nasal septal perforation.
MATERIALS AND METHODS
Seven consecutive patients with septal perforation who received the septal perforation repair with Alloderm were included in this study. The causes of septal perforations were previous nasal surgeries, trauma, chemical irritation, inflammation, or unknown. Follow-up periods ranged from 7 to 36 months.
RESULTS
Six of seven patients had successful outcomes with complete closure of their perforations. The remaining one patient had an incomplete closure, but the size of the performation was reduced with no further symptoms.
CONCLUSION
AIloderm can be used as a connective tissue and interpositional grafts in the repair of septal perforations with high success rates. Therefore, Alloderm is the viable alternative for the closure of nasal septal perforations.

Keyword

Nasal septal perforation; Acellular human dermal graft (Alloderm)

MeSH Terms

Connective Tissue
Follow-Up Studies
Humans
Inflammation
Nasal Septal Perforation
Nasal Surgical Procedures
Transplants