Korean J Otolaryngol-Head Neck Surg.
2000 Feb;43(2):188-192.
Distribution of Beta-Catenin Expression in Adenoid Cystic Carcinoma of the Head and Neck
- Affiliations
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- 1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, Korea.
Abstract
- BACKGROUND AND OBJECTIVES
beta-catenin has functions in cell-cell adhesion with a complex of proteins that link cadherin to the cortical actin cytoskeleton and signal transduction through wnt developmental pathway. In this study, we investigated the distribution of beta-catenin in adenoid cystic carcinoma according to the histologic subtypes, perineural invasion, T classification, nodal status and stage.
MATERIALS AND METHODS
Each formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with beta-catenin monoclonal antibodies and compared its staining patterns with patients' clinical characteristics.
RESULTS
In tubular subtype, there were intense membranous staining pattern than other subtypes (p<0.05). Cytoplasmic and nucleus staining were more observed in cribriform subtype (p<0.05), but weak in solid subtype (p<0.05). There were no correlation between beta-catenin staining patterns and other clinical characteristics (p>0.05).
CONCLUSIONS
It is suggest that there are mixed functional roles of beta-catenin in adenoid cystic carcinoma in tumor aggressiveness.
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