Korean J Obstet Gynecol.  2012 Dec;55(12):920-928. 10.5468/KJOG.2012.55.12.920.

Age-related distribution of anti-Mullerian hormone levels in 2,879 Korean women with regular menstruation

• Lee JE
• Park DS
• Kim ML
• Yoon BS
• Song T
• Kim MK
• Seong SJ
• Kim YJ

• KMID: 2274198
• DOI: http://doi.org/10.5468/KJOG.2012.55.12.920

Abstract

OBJECTIVE
To determine the age-related distribution of anti-Mullerian hormone (AMH) in Korean women with regular menstruation who visited fertility center.
METHODS
Between May 2010 and April 2011, serum AMH levels on day 2-3 of a spontaneous menstrual cycle were evaluated in 2,879 women of reproductive age ranging from 25 to 45 years old, retrospectively.
RESULTS
The mean age was 34.2 +/- 4.3 years. The overall mean AMH value was 3.54 +/- 2.66 ng/mL (median, 2.9 ng/mL). Serum AMH level showed an age-dependent distribution and correlated negatively with age. Among multiple regression models, the quadratic model was most appropriated to describe the relationship between AMH and age (logAMH = -1.442 + 0.225 x age-0.004 x age2).
CONCLUSION
Our data showed reference values of serum AMH in Korean infertile women with regular menstruation. These values can be used as an important information of ovarian reserve for infertility patients and clinicians.

Keyword

Anti-Mullerian hormone; Regular menstruation; Reference values

MeSH Terms

Anti-Mullerian Hormone
Female
Fertility
Humans
Infertility
Menstrual Cycle
Menstruation
Reference Values
Anti-Mullerian Hormone

Figure

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  Fig. 1 Age-related basal hormonal levels. (A) Age-related anti-Müllerian hormone (AMH) levels. (B) Age-related basal follicle stimulating hormone (FSH) levels. (C) Age-related basal estradiol (E2) levels.

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  Fig. 2 Distribution of AMH and log(AMH) levels in women with regular menstruation. (A) AMH levels in women with regular menstruation. (B) Log(AMH) levels in women with regular menstruation. AMH, anti-Müllerian hormone.

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  Fig. 3 Log(AMH) level distribution in women with regular menstruation. AMH, anti-Müllerian hormone.

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  Fig. 4 Residuals from five regression models applied to validation dataset, plotted against age, with nonparametric smoothed estimates and 95% confidence intervals. AMH, anti-Müllerian hormone.

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