Korean J Obstet Gynecol.  2012 Sep;55(9):619-628. 10.5468/KJOG.2012.55.9.619.

Epigenetic control of endocrine disrupting chemicals on gynecological disease: Focused on phthalates

• Cho HH

• KMID: 2274133
• DOI: http://doi.org/10.5468/KJOG.2012.55.9.619

Abstract

Endocrine disrupting chemicals (EDC) are some chemicals which are acting like hormones inside the body. May kinds of EDCs are acting like estrogen or anti-estrogen, so reproductive systems of male are the main targent organ. EDCs use genetic variations and epigenetic variations as main control route of diseases. When pregnant female is exposed to EDCs, the effects of EDCs on their epigenetic system affect through 3rd generation of offspring. Among many kinds of EDCs, the most notorious EDCs are dioxin and bisphenol A. Phthalates, which have so many kinds and high exposure rate, the effects of phthalate to gynecologic disease were not discovered. So in this paper, we try to summerize the effects of phthalate and new epignetic technique to evalaute the relationship among phthalate and gynecologic disease.

Keyword

Epignetics; Phthalate; Endocrine disrupting chemicals

MeSH Terms

Benzhydryl Compounds
Endocrine Disruptors
Epigenomics
Estrogens
Female
Genetic Variation
Genital Diseases, Female
Humans
Male
Phenols
Phthalic Acids
Benzhydryl Compounds
Endocrine Disruptors
Estrogens
Phenols
Phthalic Acids

Figure

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  Fig. 1 The weight of evidence that Di(2-ehtylhexyl)phthalate causes adverse developmental or reproductive effect in human and laboratory animal.

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  Fig. 2 National toxicology program of usa conclusions regarding the possibilities that human development or reproduction might be adversely affected by exposure to di(2-ehtylhexyl)phthalate.

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  Fig. 3 Selected food concentrations of di(2-ehtylhexyl)phthalate (µg/g).

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