Clinicopathologic study of ovarian granulosa cell tumors

Lee, In ho; Kwon, Yong Soon; Hahn, Ho Suap; Yoon, Seok Geun; Hong, Jae Shik; Kim, Tae Jin; Lee, Ki Heon; Shim, Jae Uk; Mok, Jung Eun; Lim, Kyung Taek

Abstract

OBJECTIVE
The aim of this study was to evaluate the clinicopathologic characteristics of granulosa cell tumor of the ovary (OGCT).
METHODS
We retrospectively reviewed the medical records of 27 patients with OGCT at our hospitals from January 1995 to December 2003.
RESULTS
The mean age was 48.3 years (24~70) and mean follow up period was 56.7 months (12~102). The most common symptom was vaginal bleeding (n=11, 40.7%). The tumors were ranging from 3 cm to 21 cm in diameter (mean: 9.9). Post-surgical FIGO stage was stage I in 20 (74.1%), stage II in 6 (22.2%), and stage III in 1 (3.7%). Endoemetrial samples were available in 21 patients and the results were endometrial carcinoma in 1 and endometrial hyperplasias in 5. Staging operation was performed in 17, unilateral salpingo-oophorectomy in 6, total hysterectomy and bilateral salpingo-oophorectomy in 2, and fertility sparing operation in 2. Postoperative chemotherapy was administered in 13 patients (48.2%). Two patients had recurred and recurrence rate was 7.4% (2/27). Two recurred patients finally died of the disease at 42 months and 103 months after first operation respectively. During follow-up period, 2 patients had 3 pregnancies and all of them delivered at term.
CONCLUSION
These results shows that most OGCT is detected in early stage and have relatively excellent survival. However, because OGCT is a slow-growing tumor and has a late recurrence, long time follow-up is required.