Korean J Obstet Gynecol.  2008 Jan;51(1):68-72.

The effect of combined treatment of Mirena(R) and Provera(R) (MPA) for chronic pelvic pain due to endometriosis

• Kim CH
• Cho MK
• Lee SM
• Oh ST

Abstract

OBJECTIVE
The degree of pain relief and complications after treatment for chronic pelvic pain due to endometirosis were evaluated.
METHODS
This study was performed in sixty three patients of endometriosis who have diagnosed by laparoscopy. They were divided in three groups by treatment regimen, Mirena(R) only group (Group A), Mirena(R) plus low-dose MPA group (Group B) and high-dose MPA only group (Group C). After six months, we evaluated the result of treatment by the degree of pain relief and complications of each treatment regimen.
RESULTS
The degree of pain relief in Group B was significantly higher than in Group A (p<0.05), and significant difference was not found between Group B and Group C. The frequency of irregular bleeding in Group B was significantly lower than Group A (p<0.05), but not than Group C. The frequency of weight gain in Group B was significantly lower than Group C (p<0.01), but not than Group A. However the frequency of breast tenderness in Group B was significantly higher than Group A (p<0.01), but not than Group C.
CONCLUSION
Mirena(R) plus low-dose MPA combined treatment is as effective as high-dose MPA treatment in pain relief with lower side-effects.

Keyword

Chronic pelvic pain; Endometriosis; Progestogen

MeSH Terms

Breast
Endometriosis
Female
Hemorrhage
Humans
Laparoscopy
Pelvic Pain
Weight Gain