Korean J Obstet Gynecol.  2005 Apr;48(4):1004-1008.

The Effect of intraperitoneal instillation of Mistletoe extract during the diagnostic laparoscopy for pain of endometriosis

• Rim SY
• Oh ST

Abstract

OBJECTIVE
Immune alternation is related to the pathogenesis and progression of endometriosis. Helixor-A, mistletoe extract, has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the effects of Helixor-A for pain of endometriosis by intraperitoneal instillation of mistletoe extract during the diagnostic laparoscopy.
METHODS
Among the paitients who visited to outpatient clinic due to chronic pelvic pain, 30 patients who had laparoscopically-confirmed endometriosis were included in this study. Helixor-A 5 mg was instilled into the posterior cul-de-sac during the diagnostic laparoscopy. Before diagnostic laparoscopy and one month after laparoscopy, the patients recorded pain scores.
RESULTS
In 11 of 30 patients (36.7%), pelvic pain of endometriosis improved after laparoscopy. In 2 of 30 patients, the side-effect of Helixor- A appeared and they were easily controlled by antihistamines.
CONCLUSION
The instillation of Helixor-A during diagnostic laparoscopy, that is essential for confirmation of endometriosis, may be helpful as a supportive treatment for treatment of pelvic pain due to endometriosis with classical treatment such as GnRH agonist therapy.

Keyword

Endometriosis; Pelvic pain; Mistltoe extract

MeSH Terms

Ambulatory Care Facilities
Endometriosis*
Female
Gonadotropin-Releasing Hormone
Histamine Antagonists
Humans
Laparoscopy*
Mistletoe*
Pelvic Pain
Gonadotropin-Releasing Hormone
Histamine Antagonists