Association of LRP5 gene polymorphisms with bone mineral density and bone responsiveness to hormone therapy in postmenopausal Korean women

Han, Chan Hee; Kwon, Dong Jin; Kim, Jin Hong

Abstract

OBJECTIVE
To evaluate the association of LRP5 gene polymorphisms with bone mineral density (BMD) and bone responsiveness to hormone therapy (HT) in postmenopausal women. DESIGN AND METHODS: The LRP5 gene polymorphisms were analyzed by restriction fragment length polymorphism (RFLP) in 229 postmenopausal women receiving HT for 1 year. The BMD before HT was check using dual-energy x-ray absorptiometer (DEXA) at lumar spine, femur neck, Ward's triangle, and greater trochanter of femur, and women in the study were classificed into 3 group, normal, osteopenia and osteroporosis according to their BMD.
RESULTS
The frequency of genotype C/C of C1677A was significanty high in osteoporosis group, and that of C/A was much low in osteoporosis group. The frequency of genotype T/C of T2268C was high in osteoporosis group, while that of C/C was low in the same group. There was no significant relationship between LRP5 polymorphisms and BMD before HT. In patients whose genotype was A/A of C3405G, C/C of T2268C, or C/C of T4037C had meaningful responsiveness to HT at the lumbar spine, regardless of their initial BMD. The Genotype C/A of C1677A also had great responsiveness to HT at the greater trochanter of femur in both osteopenia and osteoporis group.
CONCLUSION
The LRP5 gene polymorphisms were not associated with the BMD before HT, but there were some reponsiveness to HT at specific site according to genotypes of the gene.