Korean J Obstet Gynecol.  2006 Nov;49(11):2326-2334.

Small Cell Carcinoma of the uterine Cervix: Clinicopathologic characteristics and prognostic factors of the 19 cases

• Choe SK
• Jung MH
• Kim DY
• Seo DS
• Kim JH
• Kim YM
• Kim YT
• Nam JH
• Mok JE

Abstract

OBJECTIVE
To analyze the clinicopathologic characteristics, prognostic factors, and survival time of small cell carcinoma of the uterine cervix.
METHODS
The medical records of 19 patients who were diagnosed with small cell carcinoma of the uterine cervix and whose initial treatment was between October 1996 and December 2004 were reviewed retrospectively. Clinicopathologic characteristics, FIGO stage (classification according to the International Federation of Gynecology and Obstetrics), tumor size, lymph node metastasis, treatments, and overall survival were analyzed.
RESULTS
Mean age at diagnosis was 48.4 years. The overall survival time was 57.3 months, and 5-year survival rate was 52.6%. Twelve patients were in FIGO stage I or IIa and 7 were in FIGO stages IIb-IV. Immunohistochemical analysis showed positive staining for neuroendocrine marker, chromogranin and synaptophysin, in 17 patients, and negative in 2 patients. Tumor size at diagnosis was under 2 cm in 12 patients and over 2 cm in 7 patients. Disease recurred in 8 patients, and 9 patients died. Through analyzing Overall survival time, FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix.
CONCLUSION
Our study found FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix.

Keyword

Small cell carcinoma; Uterine cervix; Survival rate; Prognostic factors

MeSH Terms

Carcinoma, Small Cell*
Cervix Uteri*
Diagnosis
Female
Gynecology
Humans
Lymph Nodes
Medical Records
Neoplasm Metastasis
Retrospective Studies
Survival Rate
Synaptophysin
Synaptophysin