Korean J Obstet Gynecol.  2006 Jan;49(1):230-235.

A Case of Non-Hodgkin Lymphoma during Pregnancy

• Park HE
• Lee CJ
• Kim CH

Abstract

The occurrence of Non-Hodgkin's lymphoma (NHL) during pregnancy is very rare and this malignancy is most commonly associated with aggressive histology and dissemination. Treatment in pregnant women with low-grade lymphoma may be delayed until after delivery but women with an aggressive lymphoma must have a immediate initiation of standard chemotherapy whether to have a therapeutic abortion or not. A-32-year-old woman with NHL stage IIb complicating pregnancy is presented. The diagnosis was made aggressive lymphoma. The baby weighting 1,830 gm was delivered by normal spontaneous vaginal delivery. Following delivery, the patient received combination chemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone regimen but magnetic resonance imaging undertaken during follow-up showed leptomeningeal involvement, indicating poor prognosis. She wanted discharge ten months later from disseminated disease. We experienced a case of rapid growing Non-Hodgkin's lymphoma developed on anterior mediastineum that diagnosed during pregnancy and treated following delivery. We report this case with a brief review of literature.

Keyword

Pregnancy; Non-Hodgkin's lymphoma

MeSH Terms

Abortion, Therapeutic
Cyclophosphamide
Diagnosis
Doxorubicin
Drug Therapy
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Lymphoma
Lymphoma, Non-Hodgkin*
Magnetic Resonance Imaging
Prednisone
Pregnancy*
Pregnant Women
Prognosis
Vincristine
Cyclophosphamide
Doxorubicin
Prednisone
Vincristine