Korean J Obstet Gynecol.  2004 Dec;47(12):2359-2365.

Identification of High Risk Group of HPV associated with Cervical Cancer in Korean Women

• Lee BK
• Lee BH
• Yoon HJ
• Lee SH
• Park MH
• Kwon HC
• Lim JA

Abstract

OBJECTIVE
To identify genital HPV types and high risk group of HPV associated with cervical cancer in Korean women.
METHODS
Both Pap test and HPV-DNA test using PCR assay were performed as screening test for cervical cancer in this clinic. When patients were positive in HPV-DNA test, HPV genotyping using sequencing method and cervical biopsy were performed.
RESULTS
Frequent age group of HPV infection was 40 yrs (34.3%) and prevalence of HPV infection was 9.8%. Twenty-three types of HPV were detected. HPV 16 and 58 were detected in invasive cancer. HPV 16, 31, 33, 45, and 58 were detected in HSIL. HPV 6, 11, 18, 53, 59, and 66 were detected in LSIL. HPV 16 was most commonly detected in HSIL and invasive cancer.
CONCLUSION
HPV 16, 31, 33, 45, and 58 are included in high risk group of HPV in Korean women. It may be very effective in early detection of cervical cancer to classify HPV types included in high risk group of cervical cancer in Korean women and to perform cervical biopsy in the patients who have high risk types of HPV infection.

Keyword

HPV-DNA test; HPV-genotyping; High risk group of HPV

MeSH Terms

Biopsy
Female
Human papillomavirus 16
Human papillomavirus 6
Humans
Mass Screening
Polymerase Chain Reaction
Prevalence
Uterine Cervical Neoplasms*