Korean J Obstet Gynecol.  2004 Jan;47(1):212-219.

5 Cases of Granulosa Cell Tumors of the Ovary

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon, Korea.
  • 2Department of Pathology, College of Medicine, Inha University, Incheon, Korea.
  • 3Department of Surgery, College of Medicine, Inha University, Incheon, Korea.

Abstract

Sex cord stromal tumors (GCT) of the ovary compose just 5% of ovarian tumors. Most of them are granulosa cell tumors (GCT). There are two types of tumors, juvenile (JGCT) and adult type (AGCT), which have different clinical and histopathological features. JGCT represents only 5% of GCT. GCT is characterized by secretion of estrogen. Patients may present with vaginal bleeding in adult type, and sexual pseudoprecocity in juvenile type, as results of prolonged exposure to tumor-derived estrogen. Surgery is a principle of treatment and required for definite tissue diagnosis, staging, and tumor debulking. Survival of patients with GCT is generally excellent because most patients present with early stage disease. Because of the propensity of GCT to recur years after initial diagnosis, prolonged surveillance such as physical examination and serum tumor markers such as estradiol and inhibin is reasonable. We present 5 cases GCT, 4 AGCT and 1 JGCT, with brief review of literature.

Keyword

Juvenile granulosa cell tumor; Adult granulosa cell tumor; Sex-cord stromal tumor

MeSH Terms

Adult
Diagnosis
Estradiol
Estrogens
Female
Granulosa Cell Tumor*
Granulosa Cells*
Humans
Inhibins
Ovary*
Physical Examination
Sex Cord-Gonadal Stromal Tumors
Biomarkers, Tumor
Uterine Hemorrhage
Estradiol
Estrogens
Inhibins
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