Korean J Obstet Gynecol.  2003 Nov;46(11):2270-2275.

A Case Diagnosed to Cushing's Syndrome Caused by Adrenal Cortical Adenoma during Pregnancy after Ovulation Induction

• Kim H
• Park CH
• Choi J
• Choi EY
• Jeon YM
• Kim SK
• Shin JH
• Hong SY

Abstract

This woman was a secondary infertile patient with amenorrhea, hirsutism, and hyperprolactinemia due to excessive secretion of androgen. We had an impression that her disease was polycystic ovary syndrome, and she became pregnant after ovulation induction. Complications arised, such as hypertension, diabetes and pulmonary edema at 23rd week of pregnancy and physical findings of Cushing's syndrome were observed. Cushing's syndrome caused by adrenal cortical adenoma was diagnosed through endocrine and radiologic examination. We let her keep pregnancy through adjusting hypercorticolism with metyrapone to restrain abnormal steroidogenesis during pregnancy. After delivery, we carried out adrenalectomy through laparoscopic surgery and then can't find out any problem to be appeared to the mother and her neonate. We report this case with brief discussion.

Keyword

Cushing's syndrome; Pregnancy

MeSH Terms

Adrenalectomy
Adrenocortical Adenoma*
Amenorrhea
Cushing Syndrome*
Female
Glycogen Storage Disease Type VI
Hirsutism
Humans
Hyperprolactinemia
Hypertension
Infant, Newborn
Laparoscopy
Linear Energy Transfer
Metyrapone
Mothers
Ovulation Induction*
Ovulation*
Polycystic Ovary Syndrome
Pregnancy*
Pulmonary Edema
Metyrapone