Changes of Body Composition, Blood Concentrations of Lipid Profiles and Thyroid Hormone After Exercise Training in Hypothyroid-induced Rat

Kim, Kijin

Abstract

BACKGROUND
This study investigated the mechanism of decreased metabolic function through hypothyroidism induced rats by analyzing its metabolic markers in blood. This study also examined how treadmill exercise affects blood metabolic markers in hypothyroid rats. This study is to show the importance of exercise training for preventing hypothyroidism induced obesity, diabetes, and atherosclerosis.
METHODS
The markers of hypothyroidism and the effects of exercise interventions on thyroid functions were analyzed to measure the function of hypothyroidism in comparison with pre- and post- injections of 6-propyl-2thiouracil (PTU) on rats in the study.
RESULTS
After injections with PTU, rats manifested negative responses in bone mineral content and body composition. Before exercise intervention, PTU group showed a significantly lower value of serum T4 concentration than control group. After eight weeks of exercise training, PTU-Ex group showed a significantly higher value of serum T4 than PTU-non Ex group. Serum T3 concentration showed no significant difference between PTU-Ex group and PTU-non Ex group. Triglyceride and total cholesterol of PTU-Ex group tended to decrease compared to control and PTU-non EX group, and LDL-C of PTU-Ex group tended to decrease unlike in the control group. Also HDL-C of PTU-Ex group did not differ with the control group, and glucose level in PTU-Ex group significantly (P < 0.05) decreased compared to the control group.
CONCLUSION
Exercise training has positive effects on hypothyroidism in terms of serum T4 concentration and blood lipid profile improvement.