Korean J Obes.  2011 Sep;20(3):129-137.

The Effect of Aerobic Exercise with or without Weight Reduction on Endothelial Function in Overweight Patients with Type 2 Diabetes Mellitus

• Kim HK
• Kang SM
• Lee SY
• Park SH
• Min KW
• Han KA

Abstract

BACKGROUND
Type 2 diabetes and obesity are associated with endothelial dysfunction. We sought to determine whether weight reduction or aerobic exercise improves endothelium-dependent vasodilation in overweight type 2 diabetes patients.
METHODS
Forty overweight type 2 DM patients (BMI 27.8 +/- 2.1 kg/m2, taking metformin or no medication) were enrolled to a 12-week exercise program with or without calorie restricted diet program. The patients were grouped into either control (n = 10) group, exercise group without weight loss (n = 14) or exercise group with calorie-resticted diet (n = 16). We measured body weight, BMI, blood pressure, lipid level, HbA1c and brachial artery flow-mediated dilation (FMD) at baseline and after 12 weeks of exercise and calorie-restricted diet program. Also, apolipoprotein B, free fatty acid and hsCRP were assessed.
RESULTS
Weight loss was noticed only in the exercise group with calorie-restricted diet (-3.07 +/- 1.03 kg). FMD decreased in the exercise group with calorie-restricted diet, but remained unchanged among the control and exercise group without weight loss. Furthermore, ApoB and free fatty acid were improved in exercise group with calorie-restricted diet.
CONCLUSION
Endothelial dysfunction is improved when weight reduction is accompanied with aerobic exercise in overweight type 2 diabetes patients. Concurrent decrease in ApoB and FFA was also noted with aerobic exercise.

Keyword

Overweight; Weight reduction; Endothelial function; Endothelium dependent dilatation; Aerobic exercise; Diabetes mellitus

MeSH Terms

Apolipoproteins
Apolipoproteins B
Blood Pressure
Body Weight
Brachial Artery
Diabetes Mellitus
Diabetes Mellitus, Type 2
Diet
Exercise
Humans
Metformin
Obesity
Overweight
Vasodilation
Weight Loss
Apolipoproteins
Apolipoproteins B
Metformin