Blood Res.  2014 Dec;49(4):275-285. 10.5045/br.2014.49.4.275.

Nodal involvement of extranodal marginal zone lymphoma with extreme plasmacytic differentiation (Mott cell formation) simulating plasma cell neoplasm and lymphoplasmacytic lymphoma

Affiliations
  • 1Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ychong@catholic.ac.kr

Abstract

No abstract available.


MeSH Terms

Lymphoma*
Neoplasms, Plasma Cell*

Figure

  • Fig. 1 Radiologic and endoscopic findings. (A) An ultrasonography image showing a hypoechoic mass on the pancreas. (B) A computed tomography scan showing that this mass comprises conglomerated lymph nodes. (C) Gastroscopy showing only mild nodularity without a definite mass. (D) Mucosal nodularity is highlighted by chromoendoscopy. (E, F) Coronal and cross-sectional positron emission tomography-computed tomography images indicating fluoro-2-deoxyglucose uptake.

  • Fig. 2 Microscopic findings. (A) Lymph node biopsy revealing lymphocytic proliferation with hypersecretory plasma cells (hematoxylin and eosin [H&E], ×200) or "Mott cells" (box). (B) Gastric biopsy showing lymphoepithelial lesions (arrow) and Mott cells (arrowheads, box; H&E ×100). (C) Immunohistochemical staining for CD20, (D) CD138, (E) kappa and lambda light chains (×400), and (F) pan-cytokeratin (×200).


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Reference

1. Molina TJ, Lin P, Swerdlow SH, Cook JR. Marginal zone lymphomas with plasmacytic differentiation and related disorders. Am J Clin Pathol. 2011; 136:211–225. PMID: 21757594.
Article
2. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press;2008.
3. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. Gastrointestinal pathology: an atlas and text. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins;2008.
4. Han JJ, Ko YH, Cho EY, Kim MK, Kim NH, Ree HJ. Primary nodal marginal zone B-cell lymphoma: clincopathologic analysis of splenic and mucosa-associated lymphoid tissue type. Korean J Pathol. 2001; 35:470–476.
5. Butrym A, Prochorec-Sobieszek M, Dzietczenia J, Mazur G. Unclassifiable small B-cell lymphoma with marked plasmacytic differentiation and Mott cell formation. Leuk Lymphoma. 2014; 55:1681–1683. PMID: 24083817.
Article
6. Wohrer S, Streubel B, Bartsch R, Chott A, Raderer M. Monoclonal immunoglobulin production is a frequent event in patients with mucosa-associated lymphoid tissue lymphoma. Clin Cancer Res. 2004; 10:7179–7181. PMID: 15534090.
Article
7. Isaacson PG, Norton AJ. Extranodal lymphomas. London, UK: Churchill Livingstone;1994.
8. Kai K, Miyahara M, Tokuda Y, et al. A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies. World J Clin Cases. 2013; 1:176–180. PMID: 24303496.
Article
9. Bink K, Haralambieva E, Kremer M, et al. Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica. 2008; 93:623–626. PMID: 18326524.
Article
10. Kremer M, Ott G, Nathrath M, et al. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol. 2005; 205:92–101. PMID: 15586381.
Article
11. Lorsbach RB, Hsi ED, Dogan A, Fend F. Plasma cell myeloma and related neoplasms. Am J Clin Pathol. 2011; 136:168–182. PMID: 21757591.
Article
12. Lin P, Molina TJ, Cook JR, Swerdlow SH. Lymphoplasmacytic lymphoma and other non-marginal zone lymphomas with plasmacytic differentiation. Am J Clin Pathol. 2011; 136:195–210. PMID: 21757593.
Article
13. Morice WG, Chen D, Kurtin PJ, Hanson CA, McPhail ED. Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenström's macroglobulinemia. Mod Pathol. 2009; 22:807–816. PMID: 19287458.
Article
14. Paik S, Kim SH, Kim JH, Yang WI, Lee YC. Russell body gastritis associated with Helicobacter pylori infection: a case report. J Clin Pathol. 2006; 59:1316–1319. PMID: 17142575.
Article
15. Yoon JB, Lee TY, Lee JS, et al. Two cases of Russell body gastritis treated by Helicobacter pylori eradication. Clin Endosc. 2012; 45:412–416. PMID: 23251890.
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