Asian Oncol Nurs.  2012 Sep;12(3):195-203. 10.5388/aon.2012.12.3.195.

Effectiveness of Physical Exercise in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Affiliations
  • 1Yonsei University College of Nursing, Gangneung, Korea. sujin@gyc.ac.kr
  • 2Chung-Ang University Red Cross College of Nursing, Seoul, Korea.

Abstract

PURPOSE
To summarize and review the methodological quality of the evidence from trials examining the effectiveness of physical exercise in patients undergoing allogeneic hematopoietic stem cell transplantation (Allo-HSCT).
METHODS
Six randomized clinical trials (RCTs) were identified, reviewed for substantive results, and assessed for methodological quality.
RESULTS
Six trials met all methodological criteria on the modified Jadad score above 3 out of 5 points. Failure to blind the outcome assessor, and failure to describe the method of blinding of outcome assessor appropriately were the most prevalent methodological shortcomings. Various exercise modalities have been applied, differing in content, frequency, intensity, and duration. Positive results have been observed in part for a diverse set of outcomes, including physical and psychological performance.
CONCLUSION
The trials reviewed in this study were of moderate methodological quality. They suggest that exercise in patients undergoing Allo-HSCT may be safe and feasible, and in part patients benefit from increased physical performance both during and after transplantation. Future RCTs should use larger samples, appropriate comparison groups, and a standard of outcome measures, and examine what kind of exercise intervention (aerobic vs. resistance vs. combined) is the most effective for Allo-HSCT patients. It would be necessary to define contraindication for exercise to guarantee its safety.

Keyword

Exercise; Exercise Therapy; Hematopoietic Stem Cell Transplantation; Quality of Life

MeSH Terms

Exercise
Exercise Therapy
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Outcome Assessment (Health Care)
Quality of Life
Transplants

Figure

  • Fig. 1 Flow diagram for trial identification and selection HSCT. HSCT=hematopoietic stem cell transplantation.


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