Korean J Med.
2014 Oct;87(4):514-519. 10.3904/kjm.2014.87.4.514.
Case of Secondary Amyloidosis in a Patient with Ankylosing Spondylitis Refractory to TNF-alpha Inhibitors
- Affiliations
-
- 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. sglee@pnuh.co.kr
- 2Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- KMID: 2269232
- DOI: http://doi.org/10.3904/kjm.2014.87.4.514
Abstract
- Secondary amyloidosis occurs in patients with chronic inflammatory diseases, such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS). The major therapeutic approach to secondary amyloidosis involves controlling the underlying inflammatory disease. Tumor necrosis factor-alpha (TNF-alpha) inhibitors have revolutionized the treatment of rheumatic diseases; in many cases dramatic clinical improvement of secondary amyloidosis due to AS has been observed in response to treatment with these agents. However, the development of secondary amyloidosis associated with AS refractory to treatment with TNF-alpha inhibitors has been infrequently reported. Here, we described a case of a 37-year-old male patient with longstanding AS who was diagnosed with secondary amyloidosis due to high disease activity despite treatment with etanercept, adalimumab and infliximab.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- TNF-alpha Inhibitor Treatment in an Ankylosing Spondylitis Patient with Secondary Amyloidosis that Manifest with Diarrhea: A Case Report
- Medical Treatment of Ankylosing Spondylitis
- A Case of Tumor Necrosis Factor-alpha Inhibitors-induced Pustular Psoriasis
- Secondary Amyloidosis Development in a Patient with Juvenile Rheumatoid Arthritis on TNF-alpha Inhibitors Treatment
- Use of TNF Inhibitor in Particular Clinical Settings
