Korean J Med.  2015 Jan;88(1):60-63. 10.3904/kjm.2015.88.1.60.

Photodynamic Therapy Followed by Left Hepatectomy Used to Treat an Intraductal Papillary Mucinous Neoplasm of the Bile Duct

• Lee HS
• Oh TG
• Chung MJ
• Park JY
• Bang SM
• Song SY
• Park SW

• KMID: 2269171
• DOI: http://doi.org/10.3904/kjm.2015.88.1.60

Abstract

Mucin-hypersecreting bile duct tumors, which closely resemble intraductal papillary mucinous neoplasms of the pancreas, are rare, and both the clinical features and management thereof are poorly understood. As the biliary tract and the pancreas share a common origin, the two diseases may exhibit homologous histopathological features. Certain intraductal papillary tumors of the bile duct are associated with production of large amounts of mucin that disturb bile flow and cause severe biliary dilatation, obstructive jaundice, and cholangitis. Herein, we report on a patient with an extensive intraductal papillary mucinous neoplasm of the bile duct, involving both the right and left intrahepatic ducts. The ducts were subjected to photodynamic therapy, followed by left hepatectomy. The surgical specimen revealed an adenocarcinoma with a negative resection margin. Photodynamic therapy of the intrahepatic ducts was well-tolerated in the present case, and may serve as a useful therapeutic option for selected patients with intraductal papillary mucinous neoplasms of the bile duct.

Keyword

Bile duct neoplasms; Photodynamic therapy

MeSH Terms

Adenocarcinoma
Bile
Bile Duct Neoplasms
Bile Ducts*
Biliary Tract
Cholangitis
Dilatation
Hepatectomy*
Humans
Jaundice, Obstructive
Mucins*
Pancreas
Photochemotherapy*
Mucins