Korean J Med.  2015 Dec;89(6):681-689. 10.3904/kjm.2015.89.6.681.

Association between Change in Body Weight and Insulin Resistance in Individuals at Increased Risk of Diabetes

• Choe KJ
• Kim WJ
• Shin SY
• Woo Y
• Lee KH
• Kim EJ
• Shim MS
• Kim JY

• KMID: 2268925
• DOI: http://doi.org/10.3904/kjm.2015.89.6.681

Abstract

BACKGROUND/AIMS
The present study aimed to investigate the associations between a change in body weight from 20 years of age to the present with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes.
METHODS
From patients with a diagnosis related to an increased risk of diabetes who were examined at our endocrinology clinic from January 2012 to December 2014, the present study recruited 125 individuals between 30 and 64 years of age with hemoglobin A1c levels from 5.7 to 6.4%. The change in body weight of each patient from 20 years of age to the present was retrospectively determined, and the associations of this change with insulin resistance and several parameters of metabolic syndrome were analyzed.
RESULTS
The average gain in body weight after 20 years of age was 11.3 kg and there was no significance difference between the male and female patients. The proportion of overweight and obese patients at 20 years of age was 14%, but was 74% at the time of the visits to our endocrinology clinic. A change in body weight was significantly correlated with body mass index, insulin resistance, and waist circumference. Additionally, as the tertile of change in body weight increased, fasting insulin levels, insulin resistance, and the prevalence of abdominal obesity significantly increased.
CONCLUSIONS
In the present study, an increase in body weight from 20 years of age to the present was correlated with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes.

Keyword

Increased risk for diabetes (prediabetic state); Obesity; Insulin resistance

MeSH Terms

Body Mass Index
Body Weight*
Diagnosis
Endocrinology
Fasting
Female
Humans
Insulin Resistance*
Insulin*
Male
Obesity
Obesity, Abdominal
Overweight
Prevalence
Retrospective Studies
Waist Circumference
Insulin