Korean J Med.  2016 Jan;90(1):46-49. 10.3904/kjm.2016.90.1.46.

Rapid Progression of Diabetic Glomerulosclerosis with Crescents to End-stage Renal Disease in Newly Diagnosed Type 2 Diabetes

• Ko YS
• Yun H
• Lee EY
• Jang K
• Yi JH
• Han SW

• KMID: 2268890
• DOI: http://doi.org/10.3904/kjm.2016.90.1.46

Abstract

Diabetic nephropathy is a chronic microvascular complication of type 2 diabetes and the leading cause of end-stage renal disease. We report the case of a 34-year-old male, newly diagnosed with type 2 diabetes mellitus, who had advanced-stage nephropathy with glomerular crescents. A moderately-to-severely decreased glomerular filtration rate with nephrotic syndrome was seen at the time of diagnosis of diabetes. Proliferative diabetic retinopathy was detected, but there was no positive finding in serology tests for glomerulonephritis. Non-necrotizing cellular crescents and nodular glomerulosclerosis were observed in a kidney biopsy, and renal function declined rapidly to the end stage. We review data on diabetic glomerulosclerosis with cellular crescents and the rapid progression of nephropathy.

Keyword

Diabetic nephropathies; Disease progression; Pathology

MeSH Terms

Adult
Biopsy
Diabetes Mellitus, Type 2
Diabetic Nephropathies*
Diabetic Retinopathy
Diagnosis
Disease Progression
Glomerular Filtration Rate
Glomerulonephritis
Humans
Kidney
Kidney Failure, Chronic*
Male
Nephrotic Syndrome
Pathology