Korean J Med.  2016 Jan;90(1):7-14. 10.3904/kjm.2016.90.1.7.

Chemotherapy and Targeted Therapy beyond Adenocarcinoma of the Lung: Neuroendocrine Carcinoma

• Kwon JH

• KMID: 2268883
• DOI: http://doi.org/10.3904/kjm.2016.90.1.7

Abstract

Neuroendocrine carcinoma (NEC) has been reported to comprise 25% of lung cancer cases. NEC is classified as typical carcinoid, atypical carcinoid, large-cell neuroendocrine carcinoma, and small-cell lung cancer. Carcinoid tumors are less aggressive and surgery is the mainstay of treatment; however, patients with metastatic or inoperable disease need systemic therapy to control carcinoid symptoms and improve survival. Somatostain analogues, targeted agents including everolimus, sunitinib, bevacizumab, and conventional chemotherapy have emerged as treatment options for such patients. Large-cell neuroendocrine carcinoma exhibits more aggressive behavior and has a poorer prognosis than carcinoid tumors. No standard adjuvant and palliative chemotherapeutic agents have yet been established. This review sets out the treatment options for neuroendocrine tumors.

Keyword

Neuroendocrine tumors; Carcinoid tumor; Lung neoplasms

MeSH Terms

Adenocarcinoma*
Carcinoid Tumor
Carcinoma, Neuroendocrine*
Drug Therapy*
Humans
Lung Neoplasms
Lung*
Neuroendocrine Tumors
Prognosis
Bevacizumab
Everolimus