Korean J Med.  2016 Apr;90(4):330-333. 10.3904/kjm.2016.90.4.330.

Heart Failure Secondary to Pazopanib for Treatment of Metastatic Renal Cell Carcinoma

Affiliations
  • 1Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ashneph@wonkwang.ac.kr

Abstract

A 78-year-old man was diagnosed with renal cell carcinoma, and left nephrectomy was performed. He started pazopanib. One month later, he visited our hospital because of general weakness and dyspnea. His oxygen saturation was low. A chest X-ray showed pulmonary edema and bilateral pleural effusion. An echocardiogram showed a larger left ventricle and lower ejection fraction than observed at the previous examination. The patient discontinued pazopanib and started diuretics and digoxin. His symptoms improved and a follow-up X-ray showed improvement in the pulmonary edema with bilateral pleural effusion.

Keyword

Pazopanib; Carcinoma, Renal cell; Heart failure

MeSH Terms

Aged
Carcinoma, Renal Cell*
Digoxin
Diuretics
Dyspnea
Follow-Up Studies
Heart Failure*
Heart Ventricles
Heart*
Humans
Nephrectomy
Oxygen
Pleural Effusion
Pulmonary Edema
Thorax
Digoxin
Diuretics
Oxygen
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