Cancer Res Treat.  2016 Jan;48(1):393-397. 10.4143/crt.2014.209.

Pazopanib for Non-small Cell Lung Cancer: The First Case Report in Korea

• Jo J
• Kim JH
• Kim JY
• Hyun C
• Rhee J
• Kwon J
• Han S
• Kim W

• KMID: 2152298
• DOI: http://doi.org/10.4143/crt.2014.209

Abstract

Pazopanib is a potent multitargeted tyrosine kinase inhibitor that has been shown to have good efficacy in patients with renal cell carcinoma. A previous phase II trial demonstrated that short-term pazopanib administration was generally well tolerated and showed antitumor activity in patients with early-stage non-small cell lung cancer. Herein, we report on the case of a 66-year-old man with simultaneous metastatic squamous cell carcinoma of the lung and renal cell carcinoma who was treated with pazopanib. The patient showed an unexpected partial response and experienced a 10-month progression-free survival without significant toxicity. To the best of the authors' knowledge, this is the first report of pazopanib treatment in a non-small cell lung cancer patient in Korea. The results in this patient suggest that pazopanib may be a valid treatment option for advanced non-small cell lung cancer.

Keyword

Lung neoplasms; Drug therapy; Tyrosine kinase inhibitor; Pazopanib

MeSH Terms

Aged
Carcinoma, Non-Small-Cell Lung*
Carcinoma, Renal Cell
Carcinoma, Squamous Cell
Disease-Free Survival
Drug Therapy
Humans
Korea*
Lung
Lung Neoplasms
Protein-Tyrosine Kinases
Protein-Tyrosine Kinases

Figure

• 

  Fig. 1. Histological findings of the non-small cell lung cancer and renal cell carcinoma. (A) Lung: sheets or islands of large polygonal malignant cells with pink cytoplasm and distinct cell borders consistent with squamous cell carcinoma are observed (H&E staining, ×200). (B) Kidney: biopsy specimen of the renal mass showed alveolar growth of large polygonal cells with clear cytoplasm, uniform round nuclei, and inconspicuous nucleoli (H&E staining, ×200). Neoplastic cells have clear cytoplasm and are arranged in nests with intervening blood vessels, consistent with clear cell carcinoma.

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  Fig. 2. Computed tomography findings of the renal cell carcinoma (RCC). (A) A lobulating contoured RCC mass measuring 5×4 cm located in the left kidney is observed at the time of pazopanib initiation. (B) After 8 months of pazopanib treatment, the response of the RCC is considered to be stable disease (5.5×4.8 cm).

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  Fig. 3. Computed tomography findings of the squamous cell lung cancer. (A) A mass measuring 7×3 cm is observed in the left lower lobe of the lung at the time of pazopanib initiation. (B) The mass decreases in size to approximately 3.5×1.5 cm after 8 months of pazopanib treatment. The squamous cell cancer shows an unexpected partial response to pazopanib.

Reference

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