Korean J Nutr.  2010 Aug;43(4):342-350. 10.4163/kjn.2010.43.4.342.

Effects of Soy Protein, its Hydrolysate and Peptide Fraction on Lipid Metabolism and Appetite-Related Hormones in Rats

• Park JH
• Park MN
• Lee IS
• Kim YK
• Kim WS
• Lee YS

• KMID: 2268022
• DOI: http://doi.org/10.4163/kjn.2010.43.4.342

Abstract

This study was aimed to investigate whether soy protein hydrolysates had beneficial effects on serum and tissue lipid contents and appetite-related hormones as compared with intact soy protein. Four-week-old male Sprague-Dawley rats were fed AIN-93M diet containing high fat (18% w/w) with low protein (10% w/w). After four weeks, the rats were divided into four groups (n = 8/group) and fed experimental diets with different nitrogen sources and levels, respectively; 10% soy protein isolate (10SPI), 25% soy protein isolate (25SPI), 25% soy protein hydrolysates (25SPH) and 25% soy macro-peptide fractions (25SPP, MW > or = 10,000) for six weeks. Weight gain was significantly higher in 25% nitrogen sources-fed groups than in 10% group (10SPI). In 25SPP, perirenal fat mass and serum total lipid were significantly lower than in other groups. As for appetite-related hormones, serum ghrelin concentration was not shown to be different among groups but leptin concentration was significantly decreased in 25SPP. It can be concluded that soy macro-peptide fractions as compared with intact soy protein may have beneficial effects on reducing fat mass and serum lipid.

Keyword

soy protein; hydrolysate; macro-peptide fraction; lipid; appetite

MeSH Terms

Animals
Appetite
Diet
Ghrelin
Humans
Leptin
Lipid Metabolism
Male
Nitrogen
Rats
Rats, Sprague-Dawley
Soybean Proteins
Weight Gain
Ghrelin
Leptin
Nitrogen
Soybean Proteins

Figure

• 

  Fig. 1 The concentration of serum glucose and insulin in rats fed high fat diets containing various nitrogen sources. Groups are the same as in Table 1. Values are means ± SE of 8 rats per group. Bars with different superscripts are significantly different at p < 0.05 by Duncan's multiple range test.

• 

  Fig. 2 The concentration of serum ghrelin and leptin in rats fed high fat diets containing various nitrogen sources. Groups are the same as in Table 1. Values are means ± SE of 8 rats per group. Bars with different superscripts are significantly different at p < 0.05 by Duncan's multiple range test.

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