Arch Plast Surg.
2014 Nov;41(6):638-646. 10.5999/aps.2014.41.6.638.
Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing
- Affiliations
-
- 1Department of Surgery, National University Health System, Singapore.
- 2Department of Reproductive Medicine, KK Women's and Children Hospital, Singapore.
- 3Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
- 4Centre for Biomedical Materials Applications and Technology (BIOMAT), Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore.
- 5Department of Surgery, National University of Singapore, Singapore. thiam_chye_lim@nuhs.edu.sg
- 6Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System, Singapore.
- 7Division of Cardiac, Thoracic and Vascular Surgery, Department of Surgery, National University Health System, Singapore.
- KMID: 2267612
- DOI: http://doi.org/10.5999/aps.2014.41.6.638
Abstract
- BACKGROUND
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
METHODS
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0x3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
RESULTS
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
CONCLUSIONS
BPM is comparable to Mepitel as a safe and efficacious wound dressing.
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