Ann Dermatol.  2010 Aug;22(3):337-340. 10.5021/ad.2010.22.3.337.

A Case of Polypoid Clear Cell Acanthoma on the Nipple

• Park SY
• Jung JY
• Na JI
• Byun HJ
• Cho KH

• KMID: 2265372
• DOI: http://doi.org/10.5021/ad.2010.22.3.337

Abstract

Clear cell acanthoma (CCA) is a rare benign epidermal tumor. It usually presents as a flat nodule or dome-shaped plaque and is often localized on the legs of the elderly. We observed an unusual case of polypoid CCA on the nipple of a 14-year-old girl. At present, a few cases of CCA on the nipple area have been reported in the literature. However, CCA presented as a polypoid tumor on the nipple area has been reported very rarely. We herein report the very rare case of polypoid CCA on the nipple and suggest that CCA should be included in the clinical differential diagnosis of polypoid lesions on the nipple.

Keyword

Clear cell acanthoma; Nipple

MeSH Terms

Acanthoma
Adolescent
Aged
Diagnosis, Differential
Humans
Leg
Nipples

Figure

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  Fig. 1 A solitary polypoid brown papule on the left nipple.

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  Fig. 2 (A) Acanthosis composed of clear cells, regular elongation of rete ridges in the epidermis (H&E stain, ×40). (B) A relative sharp line is drawn between the lesion cells and normal epidermis and the epidermal surface showing parakeratotic scales (H&E stain, ×100). Inlet: Close-up view (H&E stain, ×200). (C) Exocytosis of neutrophils and intradermal neutrophil infiltration are observed (H&E stain, ×400).

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  Fig. 3 (A) Positive staining with periodic acid-Schiff (PAS) of clear cells (×40). (B) Positive staining with PAS of clear cells (×200).

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  Fig. 4 Six days after surgical excision.

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