Ann Dermatol.  2015 Feb;27(1):76-78. 10.5021/ad.2015.27.1.76.

Photodynamic Therapy in Bowen Disease of the First Web Space of the Hand

• Jung SE
• Kim SK
• Kim YC

• KMID: 2264841
• DOI: http://doi.org/10.5021/ad.2015.27.1.76

Abstract

Bowen disease (BD), or intraepithelial squamous cell carcinoma (SCC), may progress to an invasive SCC. Although surgery is preferred because of the low recurrence rate, it can result in hypertrophic scarringor contracture, particularly in lesions on the hands. We report a case of BD in the first web space of the hand, which was treated with ablative fractional laser-assisted photodynamic therapy (AFXL-assisted PDT). After multiple AFXL-assisted PDT sessions, the lesion showed no clinical or pathological abnormalities. Thus, we believe that PDT can be an alternative treatment for BD occurring in the web space of the hand.

Keyword

Bowen's disease; Photodynamic therapy

MeSH Terms

Bowen's Disease*
Carcinoma, Squamous Cell
Contracture
Hand*
Photochemotherapy*
Recurrence

Figure

• 

  Fig. 1 (A) Photo obtained after 4 treatments, which were administered after the patient was lost to follow-up for 11 months. (B) Skin biopsy showed full-thickness epithelial atypia with dermal inflammation (H&E, ×100). (C, D) After last treatment, biopsy specimens indicated that no tumor cells were present (H&E, ×100).

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