Allergy Asthma Respir Dis.  2013 Mar;1(1):79-83. 10.4168/aard.2013.1.1.79.

The correlation between the severity of atopic dermatitis classified by SCORing atopic dermatitis index and the laboratory tests

• Park GH
• Park JH
• Hwang YH
• Sung MS
• Kim SW

• KMID: 2263064
• DOI: http://doi.org/10.4168/aard.2013.1.1.79

Abstract

PURPOSE
SCORing atopic dermatitis (SCORAD) index is the best validated scoring system in atopic dermatitis (AD). But this scoring system has limitation to the interobserver and intraobserver variation. This study was designed to evaluate the correlation between the severity of AD classified by the SCORAD index and the laboratory tests.
METHODS
We evaluated 67 children admitted in the pediatric allergy and respiratory division of Busan St. Mary's Medical Center from April 1 to 30, 2011. SCORAD index was measured by one same physician. The patients were classified into mild to moderate and severe groups by SCORAD index. We identified sex, age and family history of allergic disease. We checked laboratory tests including mycoplasma immunoglobulin (Ig) M, total IgE, eosinophil count, eosinophil cationic protein, specific IgE, total protein, albumin, IgG, IgA, IgM, IgD, and inflammatory index (lactate dehydrogenase, C-reactive protein, erythrocyte sedimentation rate) and skin culture.
RESULTS
There were no statistically significant differences between two groups in age, sex, parental allergic history, skin culture, mycoplasma IgM, specific IgE, immunoglobulin, and inflammatory index. The SCORAD index has statistically significant positive correlations with serum total eosinophil count, and total IgE, and negative correlations with total protein, and albumin.
CONCLUSION
Our study suggest that serum total eosinophil count, total IgE, total protein, and albumin can be used to evaluate the severity of AD and make up for the SCORAD index.

Keyword

Atopic dermatitis; SCORAD index; Laboratory tests

MeSH Terms

Blood Sedimentation
C-Reactive Protein
Child
Dermatitis, Atopic
Eosinophil Cationic Protein
Eosinophils
Humans
Hypersensitivity
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Mycoplasma
Observer Variation
Oxidoreductases
Parents
Skin
C-Reactive Protein
Eosinophil Cationic Protein
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Oxidoreductases

Figure

• 

  Fig. 1 Correlation of SCORing atopic dermatitis (SCORAD) index with total immunoglobulin E (IgE) (A), total eosinophil count (B), eosinophil cationic protein (ECP) (C), total protein (D), albumin (E).

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