Korean J Obstet Gynecol.  2002 May;45(5):873-877.

A case of vaginal delivery in woman with congenital factor V deficiency

• Kim BJ
• Lee CH
• Kim YH
• Cho JS
• Park YW

Abstract

Congenital factor V deficiency is a rare coagulation disorder, which is genetically autosomal recessive. In 1947, Owren first described a case of parahemophilia. During childhood, ecchymosis (bruising), epistaxis, oral hemorrhage, soft-tissue hemorrhage, and postpartum hemorrhage are noted in half of the patients. Because factor V is involved in common pathway in the coagulation scheme, prothrombin time (PT) and partial thromboplastin time (PTT) are prolonged. Definite diagnosis can be made with a specific factor V assay. Fresh frozen plasma would appear to be the treatment of choice. For the first time in Korea, we experienced a case of vaginal delivery in a patient with factor V deficiency. She delivered a male baby weighing 3120gm with median episiotomy. Six units of fresh frozen plasma were transfused during delivery. After additional transfusions of fresh frozen plasma, she was discharged on fourth postpartum day without hemorrhage or hematoma.

Keyword

factor V; congenital; deficiency; fresh frozen plasma; vaginal delivery

MeSH Terms

Diagnosis
Ecchymosis
Episiotomy
Epistaxis
Factor V Deficiency*
Factor V*
Female
Hematoma
Hemorrhage
Humans
Korea
Male
Oral Hemorrhage
Partial Thromboplastin Time
Plasma
Postpartum Hemorrhage
Postpartum Period
Prothrombin Time
Factor V