Allergy Asthma Respir Dis.  2014 Jul;2(3):187-193. 10.4168/aard.2014.2.3.187.

Predicted normal values of pulmonary function tests in normal Korean children

Affiliations
  • 1Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea. hbkim@paik.ac.kr
  • 2Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center, Seoul, Korea.
  • 3Research Center for Standardization of Allergic Disease, Seoul, Korea.
  • 4Deparment of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
  • 5Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 6Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
  • 7Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
  • 8Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 9Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 10Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
  • 11Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, Korea.
  • 12Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

PURPOSE
Pulmonary function tests are useful and important methods for evaluating patients with respiratory diseases. To assess lung function, we need to establish normal values of lung function, which vary according to population, age, gender and growth, particularly in children. This study was undertaken to establish normal predicted values of pulmonary function tests and to predict renewed reference values by spirometry in Korean school children.
METHODS
Spirometric forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory flow at 25% to 75% of FVC (FEF25%-75%), and peak expiratory flow rate (PEFR) were measured in 406 healthy elementary school children (age, 6-12 years old) in May, 2012. Multiple linear regression analysis was performed for each spirometric parameter against age, height, weight and body surface area (BSA) separately for boys and girls, and derived reference equations and coefficients for all the spirometric parameters.
RESULTS
All the measured spirometric parameters were significantly correlated with age, height, weight, and BSA. FVC was higher in boys aged 6-10 years than girls at ages matched. Height showed the highest correlation coefficient for all the spirometric parameters followed by BSA, weight and age in both genders. The normal predicted values of FVC and FEV1 at 130 cm in this study using renewed reference equations were approximately in the middle compared to previous studies.
CONCLUSION
We reported here the renewed reference equations for normal predicted values of pulmonary function tests with high coefficients of determination based on updated data in healthy Korean children.

Keyword

Reference equation; Spirometry; Reference value; Pulmonary function; Children

MeSH Terms

Body Surface Area
Child*
Female
Forced Expiratory Volume
Humans
Linear Models
Lung
Peak Expiratory Flow Rate
Reference Values*
Respiratory Function Tests*
Spirometry
Vital Capacity

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