Allergy Asthma Respir Dis.  2014 Jul;2(3):157-164. 10.4168/aard.2014.2.3.157.

Allergic reactions to vaccine components

Affiliations
  • 1Department of Pediatrics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. ilove902@hanmail.net

Abstract

Vaccine contains active components, adjuvants, stabilizers, preservatives, and trace components. Adverse reactions to vaccines are rarely reported. However, all of vaccine components may elicit adverse reaction including life-threatening event in susceptible individuals, therefore raising concerns regarding safety of vaccine still continue up to date. Hypersensitivity reaction to vaccines can be classified as allergic reaction to the vaccine component, pseudo-allergic reaction, and exacerbation of allergic diseases. Hypersensitivity reactions to vaccine components rarely occurred in the population-level, while severe hypersensitivity reaction such as anaphylaxis may be consequent result in susceptible individuals. Some of components such as ovalbumin, gelatin, yeast, and latex were considered as common causes of allergic reactions to the vaccine. However, the incidence or causes of vaccine related hypersensitivity reaction in Korea were not well known. The aims of this article are to review the literatures with hypersensitivity reactions related with vaccine components, to provide detailed information about major components of vaccines commonly used in Korea, and to provide the best way of vaccination in susceptible individuals.

Keyword

Anaphylaxis; Hypersensitivity; Vaccines; Korea

MeSH Terms

Anaphylaxis
Gelatin
Hypersensitivity*
Incidence
Korea
Latex
Ovalbumin
Vaccination
Vaccines
Yeasts
Gelatin
Latex
Ovalbumin
Vaccines

Cited by  1 articles

Vaccine-related Anaphylaxis Cases Confirmed by KCDC from 2001–2016
Eui jeong Roh, Mi-Hee Lee, Kun-Baek Song, Yeon Kyeong Lee, Min-Kyung Kim, Tae Eun Kim, Eun Hee Chung
J Korean Med Sci. 2020;35(38):e337.    doi: 10.3346/jkms.2020.35.e337.


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