Korean J Obstet Gynecol.  2001 Dec;44(12):2250-2256.

Insulin-like Growth Factor-Binding Protein-1 in Cervical Secretion as a Predictor of Preterm Delivery

• Shine BK
• Kim SJ
• Park WI
• Kim JO
• Kim DW
• Hong SY
• Yoon HS

Abstract

OBJECTIVE
The phosphorylated isoforms of insulin-like growth factor-binding protein-1 (IGFBP-1) were produced by the decidua. The aim of this study was to evaluate whether the presence of phosphorylated IGFBP-1 (phIGFBP-1) in cervical secretions of pregnant women with preterm uterine contractions can predict an increased risk of preterm delivery and infectious complications. METHOD: The prospective study of 32 pregnant women who admitted under the diagnosis of preterm labor with intact membrane at gestational age of 24+0 to 36+0 weeks. Phsphorylated IGFBP-1 was qualitatively assayed using immunochromatography in cervical swab samples at the time of admission. The interval between the test and delivery, gestational age, duration of tocolysis, birth weight, CRP, ESR and the presence of neonatal infection were compared between positive and negative groups.
RESULTS
There was no differnce in age, obstetric histories and gestational age and Bishop score at the time of admission between two groups. Eight pregnacies out of 13 positive group and two pregnacies out of 19 negative group resulted in preterm birth. The sensitivity and specificity of the phIGFBP-1 test to predict preterm birth were 80.0% and 77.3%, respectively. The mean getational age and interval between the test and delivery were 38.36 weeks and 45.0 days and 35.78 weeks and 35.46 days in negative and positive group respectively. The birth weight of the babies was significantly higher in negative group. The duration of tocolysis was longer in positive group with marginal statistical significance. The CRP, ESR and WBC count were not different. One postpartum sepsis, one neonatal death and one necrotizing enterocolitis were complicated in positive group.
CONCLUSION
The presence of phIGFBP-1 is an usful marker to predict preterm birth in case of regular uterine contraction with intact fetal membranes.

Keyword

Phosphorylated IGFBP-1; Preterm delivery

MeSH Terms

Birth Weight
Decidua
Diagnosis
Enterocolitis, Necrotizing
Extraembryonic Membranes
Female
Gestational Age
Humans
Immunochromatography
Insulin-Like Growth Factor Binding Protein 1
Membranes
Obstetric Labor, Premature
Postpartum Period
Pregnancy
Pregnant Women
Premature Birth
Prospective Studies
Protein Isoforms
Sensitivity and Specificity
Sepsis
Tocolysis
Uterine Contraction
Insulin-Like Growth Factor Binding Protein 1
Protein Isoforms