A Case of Persistent Gestational Trophoblastic Tumor Associated with Complete Hydatidiform Mole with Coexisting Live Fetus

Lee, J W; Hwang, J D; Yoo, J K; Joo, I S; Park, C S; Bae, D S; Lee, J H

Abstract

Twin pregnancy with a complete hydatidiform mole and a coexisting fetus is a rare occurrence with a reported incidence of 1:10,000 to 1:100,000 pregnancies. This condition has an aggressive postevacuation behavior; it is, therefore, important to differentiate these cases from partial hydatidiform mole that rarely require treatment for late sequelae. Usually this case is diagnosed prenatally by ultrasonography. Following evacuation, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic tumor. In carefully selected patients in whom the risk of developing gestational trophoblastic tumor is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here a case of patient, developed persistent gestational trophoblastic tumor associated with hydatidiform mole with coexisting live fetus, treated by single agent systemic chemotherapy.