B-lymphocyte, T-lymphocyte and Subsets in Unexplained Recurrent Spontaneous Abortion

Cho, Chi Heum

Abstract

The depressed cell-mediated immunity in pregnant women may play an important role inthe protection of the fetus from rejection by the mother. In this of view, many studieshave been performed to evaluated of lymphocyte subsets in recurrent spontaneous abortionwomen. However, because of the discordance in published data, auther have reevaluatedperipheral blood T-lymphocyte, B-lymphocyte and subsets defined by monoclonal antibodieswith immunobead method for 37 recurrent spontaneous abortion women and 30 normal healthywomen.The results were as follows. No significant difference was observed in the componentratio of the B cell. The component ratio of T lymphocyte in study group(70.5+/-10.1%) wassignificantly decreased in control group(79.7+/-3.1%)(p < 0.001). The component ratio of Nullcell in study group(19.0+/-10.1%) was higher than control group(9.4+/-2.6%)(p < 0.001). In thecomponent ratio of T4 cell, no statistically difference were observed in both groups. In thecomponent ratio of T8 cell, study group(28.4+/-9.5%) was significantly lower than controlgroup(38.4+/-3.2%)(p < 0.001). T4/ T8 ratio in the study group(1.58+/-0.70%)was significantly higher than control group(1.09+/-0.14%)(p < 0.001).In the component ratio of T/B cell, no statistically differences were observed.In conclusion, decreased T8 cell component ratio and increased T4/T8 component ratio may be play an important role in recurrent spontaneous abortion.