Allergy Asthma Immunol Res.  2013 Jul;5(4):245-247. 10.4168/aair.2013.5.4.245.

A Case of Idiopathic Anaphylaxis Followed by Acute Liver Injury

• Kim S
• Yoon SY
• Park SY
• Kwon HS
• Cho YS
• Moon HB
• Kim TB

• KMID: 2260320
• DOI: http://doi.org/10.4168/aair.2013.5.4.245

Abstract

Idiopathic anaphylaxis is characterized by recurrent anaphylaxis without a known trigger. The coexistence of acute liver injury with idiopathic anaphylaxis is rare, even in cases of severe anaphylaxis such as shock. An unusual case involving repeated episodes of anaphylactic shock accompanied by acute liver injury is described here. A 36-year-old woman who experienced anaphylaxis due to an unknown cause was referred to our hospital because of marked elevations in her liver enzyme levels. After a thorough evaluation to determine the cause of the acute liver injury, viral infection, drug use, and autoimmune hepatitis were excluded. The episodes were accompanied by elevated liver enzymes, which suggested that this was a case of anaphylaxis followed by acute liver injury. The patient will have to use self-injectable epinephrine to prevent future hepatic failure.

Keyword

Idiopathic anaphylaxis; acute liver injury

MeSH Terms

Anaphylaxis
Epinephrine
Female
Hepatitis, Autoimmune
Humans
Liver
Liver Failure
Shock
Epinephrine

Figure

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  Figure Course of the aminotransferase levels in the present case. AST, aspartate aminotransferase; ALT, alanine aminotransferase.

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