Allergy Asthma Immunol Res.  2014 Mar;6(2):137-141. 10.4168/aair.2014.6.2.137.

The Interaction Between Allelic Variants of CD86 and CD40LG: A Common Risk Factor of Allergic Asthma and Rheumatoid Arthritis

• Lee SH
• Lee EB
• Shin ES
• Lee JE
• Cho SH
• Min KU
• Park HW

• KMID: 2260258
• DOI: http://doi.org/10.4168/aair.2014.6.2.137

Abstract

PURPOSE
Allergic asthma (AA) and rheumatoid arthritis (RA) are immune tolerance-related diseases, and immune tolerance is known to be influenced by costimulatory molecules. In this study, we sought to identify common genetic susceptibility in AA and RA.
METHODS
Two hundred cases of AA, 184 cases of RA, and 182 healthy controls were recruited at the Seoul National University Hospital, Seoul, Korea. Eight single nucleotide polymorphisms (SNPs) in five genes coding costimulatory molecules, namely, -318C>T, +49A>G, and 6230G>A in CTLA4, IVS3+17T>C in CD28, -3479T>G and I179V in CD86, -1C>T in CD40, and -3458A>G in CD40LG were scored, and genetic interactions were evaluated by multifactor dimensionality reduction (MDR) analysis.
RESULTS
MDR analysis revealed a significant gene-gene interaction between -3479T>G CD86 and -3458A>G CD40LG for AA. Subjects with the T/T genotype of -3479T>G CD86 and the A/A genotype of -3458A>G CD40LG were found to be significantly more likely to develop AA than those with the T/T genotype of -3479T>G CD86 and A/- genotype of -3458A>G CD40LG (adjusted OR, 6.09; 95% CI, 2.89-12.98; logistic regression analysis controlled by age). Similarly those subjects showed a significant risk of developing RA (adjusted OR, 39.35; 95% CI, 15.01-107.00, logistic regression analysis controlled by age).
CONCLUSIONS
Our findings suggest that a genetic interaction between CD86 and CD40LG favors the development of both AA and RA.

Keyword

Asthma; rheumatoid arthritis; CD86; CD40 ligand; genetic polymorphism

MeSH Terms

Arthritis, Rheumatoid*
Asthma*
CD40 Ligand
Clinical Coding
Genetic Predisposition to Disease
Genotype
Immune Tolerance
Korea
Logistic Models
Methods
Multifactor Dimensionality Reduction
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Risk Factors*
Seoul
CD40 Ligand

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