Outcome of Cadaveric Kidney Transplantation from Expanded Criteria Donors

Park, Ja Yong; Cho, Jang Hee; Yoon, Young Deuk; Song, Eun Joo; Jin, Mi Kyung; Yu, Chung Hoon; Jung, Hee Yeon; Lim, Jeong Hoon; Shin, Yong Bong; Choi, Ji Young; Yoon, Se Hee; Park, Sun Hee; Kim, Chan Duck; Kim, Yong Lim

Abstract

BACKGROUND/AIMS
The Korean Network for Organ Sharing (KONOS) was established in 2000, and the KONOS criteria for expanded-criteria donors (ECD) have since been applied to kidney allocation from deceased donors. The outcome of cadaveric kidney transplantation from ECD according to KONOS criteria has not been investigated.
METHODS
Seventy-seven cadaveric kidney transplants from January 2003 to December 2009 were recruited retrospectively. Factors that influence the glomerular filtration rate (GFR) of graft kidneys up to 36 months after transplantation were evaluated. Postoperative renal function and allograft and patient survival in the ECD group (n = 28) were compared with those in the standard-criteria donor (SCD) group (n = 49).
RESULTS
The GFR of graft kidneys was different according to donor GFR, age, hypertension history, and cause of brain death. In the ECD group, GFR was lower than that in the SCD group by KONOS criteria. No differences in allograft or patient survival were observed until 3 years after kidney transplantation.
CONCLUSIONS
Cadaveric kidney transplantation using the ECD by KONOS criteria is acceptable in term of graft and 3-year patient survival, although the GFR was lower in the ECD than in the SCD group.