Korean J Cerebrovasc Surg.  2006 Sep;8(3):190-194.

The Comparative Analysis of the Carotid Intima-Media Thickness and Homocysteine Level between Ischemic Stroke and Hypertensive Intracerebral Hemorrhage

Affiliations
  • 1Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea. lyb@gilhospital.com
  • 2Department of Neurosurgery, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.

Abstract

BACKGROUND: Carotid artery intima-media thickness (IMT) is an early structural marker of the atherosclerotic process and an elevated total homocysteine level is an early biochemical marker of atherosclerosis. But there are few reports about serum homocysteine level and carotid IMT between ischemic stroke, hypertensive intracerebral hemorrhage (HICH) and control group. METHOD: We studied about 173 patients with ischemic stroke, HICH and control group. Carotid IMT was defined as the mean of IMT measured by B-mode ultrasonography. Serum homocysteine level was measured by fluorescence polarization immunoassay method in fasting state. We compared serum homocysteine level and carotid IMT between ischemic stroke, HICH and control group. In statistics, One-Way ANOVA was used.
RESULTS
A significant increase in carotid IMT was noted in ischemic stroke and HICH compared with that in the control group (p<0.05), whereas there was no significant differences in carotid IMT between ischemic stroke and HICH. The serum homocysteine level of ischemic stroke was significantly higher than that of control group (p<0.05). But there were no significant differences between HICH and control group, HICH and ischemic stroke.
CONCLUSIONS
In our study, we thought a carotid IMT of ischemic stroke, HICH and serum homocysteine level in ischemic stroke can be used as early diagnostic marker. Therefore, our results address the need of further prospective clinical studies in patients with ischemic stroke and HICH in order to evaluate a possible diagnostic ability of carotid IMT and serum homocysteine level.

Keyword

Intima media thickness; Homocysteine; Stroke; Intracerebral hemorrhage

MeSH Terms

Atherosclerosis
Biomarkers
Carotid Arteries
Carotid Intima-Media Thickness*
Cerebral Hemorrhage
Fasting
Fluorescence Polarization Immunoassay
Homocysteine*
Humans
Intracranial Hemorrhage, Hypertensive*
Stroke*
Ultrasonography
Homocysteine
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